I oxazole compound sulfamethoxazole with ticarcillin - clavulanic acid cefoperazone - sulbactam combined with pairs of Pseudomonas maltophilia widowed raised outside the antibacterial activity of bacteria.docVIP

 PAGE \* MERGEFORMAT 14 I oxazole compound sulfamethoxazole with ticarcillin / clavulanic acid cefoperazone / sulbactam combined with pairs of Pseudomonas maltophilia widowed raised outside the antibacterial activity of bacteria 【Abstract】 Objective To evaluate the mouth oxazole compound sulfamethoxazole separately with ticarcillin / clavulanic acid, cefoperazone / sulbactam two kinds of β  lactamase inhibitors in combination for 30 clinical isolates of Stenotrophomonas widowed Yang single-cell bacteria in vitro antibacterial effect of the joint. Methods Design of the board, micro-broth dilution method combined with different concentrations of the two groups of antibiotics against 30 Stenotrophomonas maltophilia widowed raise the minimum inhibitory concentration, and calculate the co-inhibitory index (FIC), to determine the joint effect. Results SXT A mouth oxazole right Stenotrophomonas maltophilia widowed raise the MIC of 2 / 38, and ticarcillin / clavulanic acid, cefoperazone / sulbactam combination, its MIC50 significantly reduced to 0.5 / 9.5, FIC index distribution mainly in the 0 ~ 1. Conclusions A population oxazole sulfamethoxazole with ticarcillin / clavulanic acid, cefoperazone / sulbactam two kinds of β  lactamase / inhibitor combination, the right Stenotrophomonas widowed raise the performance of single-cell bacteria as a collaborative role and the additive effect and a synergistic interaction. 【Key Words】 Stenotrophomonas widow raising Aeromonas SXT A mouth oxazole ticarcillin / clavulanic acid, cefoperazone / sulbactam combined sensitivity In vitro antibacterial activity of compound sulfamethoxazole combined ABSTRACT Objective To evaluate the antibiotic effects of SMZ / TMP combined with TIPC / CA, CPZ / SB respectively against 30 Stenotrophomonas maltophilia. Methods The protocol was designed by checkerboard method and the MIC of two groups antibiotics against 30 Stenotrophomonas maltophilia was determined by dilution