IL-27 in hepatitis B in the pathogenesis of Progress.docVIP

 PAGE \* MERGEFORMAT 11 IL-27 in hepatitis B in the pathogenesis of Progress [Keywords:] Hepatitis B IL-27 (IL -27) is a classic spiral IL-6/IL-12 family of cytokines, studies have shown that it can promote the differentiation of helper T cells and enhance anti-T-lymphocyte activity, can be through a variety of mechanisms to promote the occurrence of Th1-type immunity and induce B cell transformation, and a major role in the innate immune system and the adaptive immune system play a wide variety of cells in the immune regulatory role. Of the immune system function and immune and genetic factors in the pathogenesis of hepatitis B has played a very important role, particularly cell-mediated immunity in liver cell damage and viral clearance plays an important role. Clear HBV (Hepatitis B virus) rely mainly on cellular immunity, that is, under the action of Th1 type cell differentiation and maturation of cytotoxic T lymphocyte (CTL), CTL by clearing HBV infected cells and secretion of cytokines and clear the HBV [2]. In this article, will be discussed in some information about IL-27 in hepatitis B pathogenesis. 1 IL-27 structure IL-27 is a heterodimer of cytokines by the IL-27p28 and EBI3 subunits [1]. 1996 EBI3 subunits have been identified, its structure and IL-12, P40 homologous subunits. IL-27p28 subunit is a helical cytokine tetramer in 2002, Kastelein and so found in the gene pool of the p28 subunit of IL-27 genes with the p35 subunit of IL-12 and IL-6 gene with the derived high, further define the IL-27 is the IL-12 family of new members. IL-27 and IL-12, IL-23 structurally similar, but not between the sub-structures connected by disulfide bonds, this structure allows us in theory, in vitro and mouse model through the synthesis of the two different environments subunits in order to further detailed study of IL-27 biological functions. So far that there is no EBI3 participation, p28 synthesis with little or can not be secreted; but Stumhofer [3] and other