IL2 PSP analgesic effect in studies.docVIP

 PAGE \* MERGEFORMAT 8 IL2 PSP analgesic effect in studies Study: India and its chapter Liuyuan Rong Zhen-Lun Gu [Abstract] PSP (polysaccharopeptide, PSP, and the analgesic effect of analgesic mechanisms. [Method] 60 SD rats were randomly divided into 5 groups, namely normal control group, different doses of PSP group and the meperidine positive control group. PSP continuous administration 6d, electrical stimulation of tail screaming pain threshold determination to observe the impact of PSP on pain threshold. simultaneous determination of PSP on the base of the medial hypothalamus (MBH interleukin 2 (IL 2) and interleukin-2 receptor (IL 2R expression. [results] PSP rat after treatment compared with the normal group, the pain threshold increased significantly and dose-effect relationship. PSP can increase the rat MBH region IL 2 the number of positive cells in the immune response and reduce the distribution of IL 2R-positive granules. [Conclusion] PSP a central analgesic effect, the analgesic effect of target may be located inside the base of the hypothalamus. mechanism may stimulate T cells with PSP secretion of IL 2, IL 2 into the brain and with the MBH in the IL 2 receptor binding. [Keywords:] PSP; analgesic; interleukin-2; medial basal hypothalamus A total of 80 rats were divided randomly into high dose of psp, medium dose of psp, low doses of psp, positive control group, negative control group.After intragastric (ig) administration of different (high, medium and low) doses of PSP for 6 days, The tail stimulation vocalization test was used to observe the analgesic effect of PSP.The IL 2 and IL 2R expression in mediobasal hypothalamus (MBH) was studied immunohistochemically. [Results] After intragastric (ig) administration of PSP for 6 days , the pain threshold was increased significantly and a dose effect relationship was observed. After PSP administration the IL 2 expression in MBH was increased, while the IL 2R expression in MBH was decreased.