IL21 regulation of the immune balance of the colon cancer cell.docVIP

 PAGE \* MERGEFORMAT 16 IL21 regulation of the immune balance of the colon cancer cell Of: Zhang Zhenya Zhang Chen Xueqian safety of weight Yue Ming Bao-En Yu [Abstract] Objective To observe and colorectal cancer cells in mice inoculated Colon26 shift Th1/Th2 balance, bearing in order to adjust the mouse Th1/Th2 balance of IL 21 to observe the regulation of cellular immune balance of colorectal cancer. Methods of 30 randomly selected patients with colorectal cancer, detected by flow cytometry of Th1/Th2 cell ratio and serum concentrations of IFN and IL 4. the other paw pads on the inside of the skin in mice inoculated with high secretion of IL 21 in Colon26/IL 21 cells, compared to observe the small The growth of mouse tumors and the immune equilibrium. The results 30 patients with colorectal cancer and 30 cases of normal Th1/Th2 ratio were 0.74 + -0.27 and 1.26 + -0.9, the determination of serum IFN concentrations were ( 6.26 + -1.43 and (9.18 + -2.31pg/ml, IL 4 concentrations measured values were (8.88 + -1.30 and (5.20 + -1.71pg/ml, IFN / IL 4 Determination of the ratio values were 0.70 + -0.10 and 1.82 + -0.35, the difference was obvious. mice inoculated Colon26/IL 21 cells to the tumor continued to grow gradually reduced after 16 d, IFN in serum was significantly higher in inoculated Colon26 cell group continued growth of tumors in mice increased serum IL 4 concentrations higher than Colon26/IL 21 cell group, immune balance to shift the direction of cellular immunity. Conclusion colorectal cancer patients compared with normal cells decreased immune function, immune balance (Th1/Th2 balance to the Th2-type shift, IL 21 can enhance Th1-type cellular immune function, regulate Th1/Th2 cell ratio, correct the immune imbalance, effectively kill tumor cells. [Keywords:] immune balance, IL 21, colorectal cancer, Colon26 cells The development of malignant tumors are often associated with immune dysfunction related to regulation of tumor immunity i