In patients with liver diseases of anti-LKM-1 and anti-SLA - LP autoantibodies in the detection and characterization.docVIP

 PAGE \* MERGEFORMAT 8 In patients with liver diseases of anti-LKM-1 and anti-SLA / LP autoantibodies in the detection and characterization Authors: Feng Xia, Yan Hui-ping, Liu Yanmin, Huang, Tan Yu-fen, Liu Yan, Dong-Mei Ma [Keywords:] LKM-1; SLA / LP; hepatitis; autoimmune [Abstract] Objective To study abnormalities in liver function in patients with liver and kidney microsomal antibody and soluble liver antigen / liver pancreas antibodies and immune characteristics of the meaning. Methods abnormal liver function in patients with alanine aminotransferase (ALT)amp;gt; 40 u / L in plasma of patients with 5500 cases, were used to detect liver and kidney microsomal antibodies, soluble liver antigen / liver pancreas antibodies and related antibodies, access to clinical data. Results 5500 cases detected in plasma SLA / LP-positive in 8 cases, accounting for 1.45 ‰ , LKM-positive in 4 cases, accounting for 0.73 ‰ . 12 cases of positive cases, hepatitis B and hepatitis C infection is now evidence of disease had 1 cases and in 2 cases. Most patients also accompanied by ANA, AMA, SMA, and (or) LSP and other antibodies. Conclusions The anti-LKM-1 and anti-SLA / LP occur in patients with liver disease in our country the proportion of low-and anti-LKM-1 and anti-SLA / LP is a characteristic of autoimmune liver disease antibodies, detection of this antibody in diagnosis of autoimmune hepatitis significance. [Keywords:] LKM-1; SLA / LP; hepatitis; autoimmune Study on LKM-1 and SLA / LP in Chinese patients with liver diseases [Abstract] Objective To study the positive rates of LKM-1and SLA / LP in Chinese patients with liver diseases and analyse its characteristics.Methods 5500 sera of liver diseases with ALTamp;gt; 40 u / L were collected in 5 years.LKM-1, SLA / LP and related autoantibodies were tested by immumofluorescence assay and euroassay.Results Of 5500 sera only 4 cases (0.73 ‰ ) were positive for both LKM and LKM-1 antibodies.8 cases were positive for SLA / L