Insulin receptor non-peptide small molecule agonist of the research.docVIP

 PAGE \* MERGEFORMAT 10 Insulin receptor non-peptide small molecule agonist of the research [Abstract] has found a number of non-peptide small molecules that can simulate the role of insulin activation of insulin receptor-mediated signal transduction pathway for the development of new anti-diabetes drugs provide a new strategy. This paper reviews the insulin receptor at home and abroad in recent years, non-peptide small molecule agonist of research progress, to discuss traditional Chinese medicine were screened from the insulin receptor non-peptide small molecule agonist prospects. [Keywords:] insulin receptor; non-peptide small molecule agonist; traditional Chinese medicine Diabetes is the most common endocrine disease. With the development of production, improved living standards and population life expectancy, the rapidly growing incidence of diabetes has become a global medical problem. At present, all patients with type 1 diabetes and oral diabetes drugs control blood glucose levels in patients with type 2 diabetes need to use insulin therapy. However, insulin is a peptide molecule, oral digestion would be the loss of activity, but rely on injections for treatment, cause great inconvenience to the patient and suffering. Therefore, looking for oral non-peptide small molecule agonist of insulin will be cause for concern. China’s rich resources of Chinese medicine, Chinese medicine treatment of diabetes has a long history, development and effective use of Chinese medicine with anti-diabetic effects, from screening extracts of insulin receptor non-peptide small molecule agonist, on China’s pharmaceutical industry is significant. An insulin receptor non-peptide small molecule agonist of the research significance Diabetes is generally divided into type 1 diabetes and type 2 diabetes. Type 1 diabetes is usually due to pancreatic islet β -cell secretion of insulin which led to reduced capacity due to a lack of insulin; the cause of type 2 diabetes are very