Integrin αvβ3 in tumor angiogenesis in the role of.docVIP

 PAGE \* MERGEFORMAT 28 Integrin αvβ3 in tumor angiogenesis in the role of Author: HUANG Yunpeng LIN Jian-Hua Zhi-Xiong Lin Abstract-integrin is an important adhesion molecule, integrin αVβ3 integrin is an important member of the family. As endothelial cells and extracellular matrix of the bridge, integrin αVβ3 by regulating endothelial cell adhesion, migration, proliferation, apoptosis and other functions, in the process of tumor angiogenesis play an important role. Integrin αVβ3 monoclonal antibodies and antagonists can inhibit tumor angiogenesis, may be a new way to treat cancer. Keywords: integrin αVβ3 tumor angiogenesis Integrin (integrins) for the cell adhesion molecule-important member of the family is one of a group of widely distributed in the cell surface transmembrane glycoprotein receptor, mainly mediated cell-cell, cell and extracellular matrix (extracellular matrix, ECM) between adhesion and ECM-mediated cell and two-way between the signal transduction, cell adhesion, proliferation, differentiation, transfer, play an important role in regulating apoptosis. Recent studies have shown that integrins in tumor angiogenesis play an important role in the process, in which the role of integrin αVβ3 is particularly important. In this paper, αVβ3 in the role of tumor angiogenesis were discussed. An integration of the basic structure and function of prime Integrin α and β subunits by non-covalent bonding to form a transmembrane glycoprotein heterodimer have so far been found in 18 different α-subunits and 8 β subunits to form at least 24 species of integrin [1]. Integrin ligand identified is the variety of ECM components such as fibronectin (fibronectin, FN), laminin (laminin, LM), glass-adhesion protein (vitronectin, VN), platelet-reactive protein -1 (thrombospondin -1, TSP-1) and von Willebrand factor (von Willebrand factor, vWF) and so on. Most of the Integrin and ECM molecules after the formation of complex cell