Intensity-modulated radiotherapy of nasopharyngeal carcinoma in early Cheng residual lesions after fractionated stereotactic radiotherapy.docVIP

 PAGE \* MERGEFORMAT 6 Intensity-modulated radiotherapy of nasopharyngeal carcinoma in early Cheng residual lesions after fractionated stereotactic radiotherapy Authors: Ruo-Zheng, Liu Kai, Wang multi-ming, Gupur [Abstract] Objective preliminary assessment of fractionated stereotactic radiation therapy for nasopharyngeal cancer 3D conformal intensity modulated radiation therapy to push the amount of residual disease treatment clinical value. Methods 31 cases of nasopharyngeal carcinoma three-dimensional conformal intensity modulated radiation therapy in patients with residual disease, the application produced by Brain LAB, Germany stereotactic radiotherapy system, pushing the amount of radiation. 6MV X-ray median dose of 16Gy (12 ~ 20Gy). 1 to 3 centers, reference dose curve selected as 70% ~ 90%. Fragmented: 4Gy / time interval of 1 ~ 3d. The results of this group of patients 1,2, 3-year local control rate of nasopharyngeal were 97.0%, 92.0% and 86.0%; 1,2, 3-year overall survival rates were 100%, 94% and 90%; 1,2,3 year disease-free survival rate was 97%, 90% and 82%. No other special complications. Conclusion Patients with newly diagnosed nasopharyngeal carcinoma in three-dimensional conformal intensity modulated radiation therapy given after the residual lesions increase the amount of stereotactic radiation, able to achieve better local control rate and survival rate. [Keywords:] nasopharyngeal carcinoma; three-dimensional orientation; three-dimensional conformal intensity modulated radiation therapy; prognosis Nasopharyngeal cancer due to anatomical constraints and the characteristics of local tumor growth and invasion, radiation treatment of nasopharyngeal carcinoma is the preferred method. However, after radiotherapy in local remnants of one of the reasons for treatment failure [1]. There are the reports [2], about 10% of nasopharyngeal carcinoma after radiotherapy in patients with residual disease, 30% local recurrence. Although the amount of conv