Interleukin-8 and chronic obstructive pulmonary disease research.docVIP

 PAGE \* MERGEFORMAT 25 Interleukin-8 and chronic obstructive pulmonary disease research Keywords: Interleukin-8 with chronic obstructive pulmonary disease Interleukin-8 (IL-8) is a powerful neutrophils, T lymphocytes and basophil chemotactic factor, and can activate neutrophils, is an important inflammatory mediators. IL-8 mainly from monocyte-macrophage cells, on neutrophil chemotaxis and a stronger activation to participate in the formation of local inflammation is a newly discovered inflammatory cytokines. Chronic obstructive pulmonary disease (COPD) is a kind of disease characterized by airflow limitation status, airflow limitation is usually progressive development was not fully reversible, more with the harmful gases and abnormal lung inflammation. This airway inflammatory diseases, the Department of neutrophil interaction with the gas-wall results, inflammatory process is affected by the regulation of cytokines, while IL-8 in chronic airway inflammation plays an important role. IL-8 is now on the biological characteristics and function, IL-8 receptor, IL-8 and the relationship between COPD are reviewed. 1 IL-8 biological characteristics of In 1987, Yoshimura and his colleagues for the first time from the lipopolysaccharide (LPS) and phytohemagglutinin (PHA) stimulated human blood mononuclear cell culture supernatants, and purified extract of a novel neutrophil chemotactic Activity of protein, then found that monocyte-derived neutrophil chemotactic factor (MDNCF), monocyte-derived neutrophil activating peptide (MONAP), neutrophil-activating factor (NAF), lymphocytes derived neutrophil activating peptide (LYNAP) and granulocyte chemotactic peptide molecular characterization of cytokines, such as exactly the same part of chemokine (CXC) subfamily (α sub-tribe) members. Held in London in 1988, an international academic conference on the factors renamed MONAP/IL-8. IL-8 molecular weight of 8.3kD, heat resistance, alkali resistance, t