Is simply too much aldosterone in salt diets lead to myocardial damage SD.docVIP

 PAGE \* MERGEFORMAT 19 Is simply too much aldosterone in salt diets lead to myocardial damage SD Of: Wang Yan Li Cheng Hua Chuan Zhang Shaoling [Abstract] [Objective] is simply too much aldosterone in potassium-salt diet and normal SD rats under conditions of myocardial structure and its possible mechanism. [Method] is potassium salt diet and under, male SD rats were randomly divided into 3 groups: control group, aldosterone group, and aldosterone + spironolactone group, n = 10. 4 weeks, weekly measurements of blood pressure, end of the experiment myocardial structural changes, Determination of malondialdehyde in serum and myocardium (MDA) levels and superoxide dismutase (SOD) activity, ELISA determination of serum high sensitivity C-reactive protein (hsCRP) levels, immunohistochemical detection of myocardial ED-1 expression, fluorescence real-time PCR, gene expression of p47phox and p22phox . [Results] aldosterone for 4 weeks, SD blood pressure increased slightly (P lt;0.05), but there is a change of myocardial ultrastructure; the same time, serum and myocardial MDA levels and SOD activity, heart and serum hsCRP p47phox gene expression levels were increased (P all lt;0.05), but no inflammatory cell infiltration of local heart. spironolactone can reverse the effects of aldosterone, and not rely solely on blood pressure reduction. [Conclusion] is simply too much aldosterone in potassium-salt diet and normal conditions SD rats under induced myocardial injury and oxidative stress increased the heart of these changes prior to the emergence of local inflammatory reaction. [Keywords:] aldosterone; heart; oxidative stress; mineralocorticoid receptor Abstract: [Objective] To investigate the direct cardiac injury of aldosterone alone in SD rats under normal salt diet and normokalemia and its possible mechanism. [Methods] Male SD rats receiving normal salt diet and potassium chloride supplementation for 4 weeks were divided into three groups (n = 10 in each