Ischemia modified albumin testing and clinical applications.docVIP

 PAGE \* MERGEFORMAT 13 Ischemia modified albumin testing and clinical applications [Keywords:] Detection of Ischemia Modified Albumin clinical application of Ischemia modified albumin is a reflection of more recent studies of biochemical markers of myocardial ischemia can be used as sensitive indicators to help early diagnosis of ischemia to the irreversible stage of the disease, therapeutic intervention to achieve improved patient outcomes and reduce mortality purposes. is the detection of ischemia modified albumin and clinical application are reviewed. 1 IMA discovery Ischemia modified albumin (IMA), also known as cobalt binding protein (ACB) .1990, the emergency doctors discovered a heart attack, ischemic human serum albumin (HSA) may change the chemical properties, and found that HSA is a circulating protein, the amino-terminal sequence is unique to humans, and transition metals (such as Co, Cu and Ni) have a strong binding capacity [1]. and other species of animal albumin compared to the metal binding sites biochemical factors susceptible to be degraded. Bar-Or D, etc. [2] in finding the diagnosis of acute coronary syndrome (ACS) of biochemical markers in patients with serum albumin was observed with exogenous cobalt ions (Co2 +) binding reduced capacity, using albumin - determination of cobalt binding test IMA, detection of myocardial ischemia. 2, specimen collection, preservation Treatment in patients with cubital vein blood samples collected during 3 ~ 4 mL, do not use any preservatives, anticoagulants and coagulant, the full aggregation at room temperature, centrifugal separation of serum; in 5 hours to complete tests or serum samples quickly frozen to - temperature of 20 or less, frozen samples at room temperature prior to analysis of its home to melt and mix well and then were determined [3-5]. Sinha et al [6] that dealt with this method serum samples, the test results with fresh samples was not significant. 3 IMA test IMA i