Ischemic stroke in the treatment of cerebral protection overview of Western.docVIP

 PAGE \* MERGEFORMAT 13 Ischemic stroke in the treatment of cerebral protection overview of Western [Keywords:] ischemic stroke, cerebral infarction, in Western medicine, brain protection, neuroprotection Ischemic stroke is a common vascular disease, morbidity, disability high, its complex mechanism of brain damage, cerebral ischemia caused by a series of pathological physiological changes. Treatment to prevent or reduce the formation of cerebral infarct size restore the cerebral blood supply, and promote infarct peripheral blood circulation, improve metabolism of brain tissue. At present more and more emphasis on domestic and foreign scholars of brain ischemic stroke protective agent research, this article on Western medicine in the treatment of ischemic stroke in terms of cerebral protection status are summarized below. First, the western medicine treatment of cerebral protection 1. Calcium channel blocker A large number of Ca2 + influx is the key to trigger neuronal death, while the Ca2 + channel blocker, is the first study for acute ischemic stroke neuroprotective agents. Nimodipine is the most commonly used clinical Ca2 + channel blockers, can be through the blood-brain barrier, inhibition of transmembrane Ca2 + flow into neurons and intracellular Ca2 + release to prevent Ca2 + overload, to prevent the activation of protein degrading enzymes, reduce frame damage to neurons after ischemia, which in turn has neuroprotective effects. Such drugs include up to Luo horizon, nicardipine, isradipine, flunarizine and so on. 2. Excitatory amino acids (EAA) receptor antagonist Study confirmed that, in the ischemic brain tissue, a large number of the release of EAA, EAA excitatory cerebral ischemic toxicity, pathological changes in cerebral ischemia is a major component of the postsynaptic receptor. Application of EAA receptor antagonist agents can inhibit the excessive release of EAA neurons in response to activation by blocking Ca2 + into the ne