Its main component of bee venom melittin progress in anti-tumor mechanism of.docVIP

 PAGE \* MERGEFORMAT 12 Its main component of bee venom melittin progress in anti-tumor mechanism of [Keywords:] Summary of Bee Dufeng toxin tumor Worker bee venom and bee venom gland is secreted with a clear aroma venom stored in the poison sac, the sting when the needle discharge from the sting. Its chemical composition is complex, including peptides, enzymes and non-peptide substances. main active ingredient is melittin, bee venom neuropeptides, phospholipase A2, hyaluronidase, dopamine and histamine. which melittin is the main component of bee venom, approximately 50% of the dry weight of bee venom [ 1]. melittin with high biological activity, pharmacological studies have shown that it has anti-inflammatory, analgesic, inhibiting platelet aggregation, anti-AIDS and other anti-tumor effect. In recent years, anti-tumor effect of bee venom potential clinical application has attracted much attention. Antitumor mechanism of 1 1.1 directly kill tumor cells Zhang et al [2] The wasp toxin on mouse tumor model (S180) and treatment of tumor killing effects in rats and found that bee venom on the mouse tumor cells Hu has a direct killing effect and a therapeutic effect. The main activity of bee venom melittin in a variety of components of experimental anti-tumor effect of a [3-4], and 1 μmol / L concentration of melittin to prevent the proliferation of tumor cells, without inhibiting normal cell growth and cloning rate [5]. generally considered that melittin dissolved mitochondrial membrane, the cell’s normal breathing is inhibited, and thus tumor tissue the process of oxidative phosphorylation was inhibited by oxidative damage, leading to tumor growth inhibition. Immunomodulatory effects of 1.2 1909, Paulehrlich proposed immune response against the tumor is the main mechanism for the body concept. In general, the body’s immune system has three main functions, namely defensive protection of infection of pathogenic microorganisms to remove the body