Itraconazole side effects caused by literature analysis of 38 cases.docVIP

 PAGE \* MERGEFORMAT 10 Itraconazole side effects caused by literature analysis of 38 cases [Abstract] Objective: To investigate the cause of itraconazole adverse drug reactions (ADR) and the general rule. Methods: Check lt;”China Hospital Knowledge Warehouse (CHKD) full-text journal databasegt;gt; from 1994 to 2009, ADR caused by itraconazole in the literature 32 (38 cases), the statistical analysis. Results: ADR caused by itraconazole 19 to 60 years in the high incidence occurred in the 1 to 7 days after treatment (60.53%), clinical manifestations complex and diverse, involving multiple body organs or systems, ADR is the major drug eruption and liver dysfunction. Conclusion: Clinicians and pharmacists should pay attention to itraconazole due to ADR, insist on rational drug use. [Keywords:] Itraconazole; adverse reactions; Literature Analysis Itraconazole (Itraconazlecapsule), also known as Sporanox, is a synthetic broad-spectrum antifungal agents, for the triazole derivatives. Cytochrome P450 by interfering with the activity of fungi that can not synthesize ergosterol, resulting in fungal cell damaged, so cell death. clinically used in the treatment of refractory onychomycosis. can be used for treatment of Candida vulvovaginitis, urethritis male candidiasis, skin diseases and fungal meningitis Yinzhu embolism. In recent years, With the amount of the drug in clinical increase in its adverse reactions (ADR) reports are becoming increasingly more, and some even more serious reaction. To discuss the general rules of ADR occurrence and characteristics of this by searching the literature, carried out its ADR investigation and analysis, designed to provide a reference for the clinical use of drugs. 1 Clinical data and methods 1.1 Source By lt;”China Hospital Knowledge Warehouse CHKD journal full-text databasegt;gt; to retrieve and review the relevant original literature, January 1994 ~ February 2009 between the domestic public offering of medical j