Kangnaoling Capsule dementia rats mechanism of free radical injury.docVIP

 PAGE \* MERGEFORMAT 9 Kangnaoling Capsule dementia rats mechanism of free radical injury Study: Quarter Xuming, Wang Fang, Zhang Guiju, Lu Guohui [Abstract] Objective Kangnaoling Capsule on dementia free radical damage neurons and the protective effect of caspase-3, Bcl-2 expression. Methods of vascular dementia rat model, Chinese intervention, the use of spectrophotometry Total detection of superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) levels, caspase-3 fluorescence spectrophotometer expression, flow cytometry the expression of Bcl-2. Results Kang Alzheimer brain capsule significantly reduced MDA content in rats, increased SOD, NO content, reducing the expression of caspase-3, increased expression of Bcl-2. Conclusion Kangnaoling dementia capsule on ischemia-reperfusion injury in rats with free radical protective effect The mechanism and enhanced the expression of Bcl-2, reducing the expression of caspase-3. [Keywords:] Kangnaoling capsule, vascular dementia, free radical damage, Bcl-2, caspase-3, rat Abstract: Objective To study the protection of Kangnaoling capsule to free radical injury and influence on the expression of caspase-3 and Bcl-2 in neuron of VD rat. Methods VD rat model was duplicated. Using spectrophotometry to detect contents of SOD, MDA and NO, spectro-fluorimeter to detect the expression of caspase-3, spectrophotometric method to detect the expression of Bcl-2 after traditional Chinese medicine interference. Results Kangnaoling capsule can markedly reduce the contents of MDA, raise contents of SOD and NO, degrade the expression of caspase-3, enhance the expression of Bcl-2. Conclusions Kangnaoling capsule can markedly protect VD rat from free radical injury, which probably correlated with increasing expression of Bcl-2, decreasing expression of caspase-3. Keywords:: Kangnaoling capsule, vascular dementia, free radical injury, Bcl-2, caspase-3, rat Kangnaoling capsule by the Chuanxiong, Angelica,