Jianshen granules in diabetic nephropathy and renal tissue TGF1 ET1mRNA renal function.docVIP

 PAGE \* MERGEFORMAT 11 Jianshen granules in diabetic nephropathy and renal tissue TGF1 ET1mRNA renal function Of: Jing Xu Limei Zhang Wenlong Dong Jianwei Ma Xinying CAI Wei Hanlin [Abstract] [Objective] To observe the effect of DN Jianshen granules of rat kidney tissue TGF 1, ET 1 mRNA and renal function in mice. [Methods] 5 / 6 nephrectomy method of intravenous injection of STZ rat DN animal model, and randomly divided into Jianshen granules, benzene Rapley, kidneys, health, pathology and normal control group, renal function detected by biochemical methods, PCR method for detection of renal tissue TGF 1, ET 1 mRNA, histopathology organizational structure of the kidney were observed. [Results] Jianshen granules in rat serum Cr, BUN level of less than benzene Rapley, Paul Shen Kang and pathological control group (P lt;0.05 or P lt;0.01, Jianshen granule group Kidney tissue TGF 1, ET 1 mRNA expression was significantly lower than the other three groups (P lt;0.05 or P lt;0.01, renal pathology structure than the other three groups had significant improvement, DN Jianshen granules reduce blood sugar, urine protein and blood lipids was superior to benzene Rapley, Paul Shen Kang and pathological control group (P lt;0.05 or P lt;0.01. [Conclusion] Jianshen DN granules can improve renal function, and lowering blood glucose, adjusting blood lipids, reduced kidney DN TGF 1, ET 1mRNA role. [Keywords:] diabetic nephropathy, Jianshen granules, transforming growth factor 1, endothelin-1 Abstract: [Objective] To explore the effects of TCM Jianshen Granule on kidney TGF 1, ET 1mRNA and function of rats. [Method] Take 5 / 6 kidney resection and tail vein injection of STZ to copy rats DN model, and randomly divide them into groups of Jianshen Granule (1Benazeprilat (2, Baoshen Kang (3, pathological control (4and normal control (5, take bio chemistry method to observe kidney tissue. [Result] The TGF 1 and ET 1 mRNA expression in group 1 is markedly lower than other