Kawasaki disease with intravenous immunoglobulin therapy.docVIP

 PAGE \* MERGEFORMAT 5 Kawasaki disease with intravenous immunoglobulin therapy [Keywords:] Kawasaki disease; intravenous injection; immune globulin Kawasaki disease (Kawasaki disease, KD) the cause is not yet fully understood, although evidence indicates that its incidence may be related to infection, but has not yet been confirmed. Has confirmed the existence of the disease to immune activation of acute phase activation as the main changes in abnormal immune regulation, the main pathological changes of systemic non-specific vasculitis, multiple violations of coronary arteries, some children with the formation of coronary artery aneurysms (Coronary aneurysm, CAA ), in which a small number of children with coronary artery stenosis or thrombosis may occur even lead to myocardial infarction, has therefore become a common acquired heart disease in children. At present there is no disease-specific therapy, the acute phase of treatment aimed at controlling non-specific systemic vascular inflammation and prevent the formation of coronary aneurysms and thrombotic occlusion. Treatment measures and drugs, including: intravenous injection of gamma globulin (intravenous immune globulin, IVIG, or intravenous gamma globulin, IVGG), aspirin (Asprin, ASA), corticosteroids, other treatments, and IVIG treatment of non-responders. Kawasaki disease is now on intravenous immunoglobulin therapy to talk about the following. 1 IVIG treatment of the historical evolution of Kawasaki disease In 1983, Japanese scholars to IVIG treatment of Kawasaki disease was first reported and confirmed that 400 mg / (kg * d), used in conjunction more effective than 5 d less than the total amount of any program [1]. In 1984, Furusho first reported in the Lancet with IVIG plus ASA with ASA treatment alone, compared to more effectively reduce the incidence of coronary artery lesions [2]. Subsequently, in the United States set up a multi-center research group, and carried out two high-dose gamma gl