Kashin-Beck disease etiology and pathogenesis of Progress and Prospects.docVIP

 PAGE \* MERGEFORMAT 39 Kashin-Beck disease etiology and pathogenesis of Progress and Prospects [Abstract] Kashin-Beck disease is a localized, abnormal bone and joint disease, so far unknown reasons, at present the most important regions in western China, there is no effective treatment measures. In this paper at home and abroad based on the study analyzed the three-KBD kinds of research progress and cause hypothesis outstanding issues, combined with its team of recent progress, proposed addition to the classic KBD cartilage necrosis also manifestations of excessive apoptosis of chondrocytes and “dedifferentiation” , Kashin-Beck disease differentially expressed genes in cartilage cells, serum protein expression profiling and short tandem repeat polymorphism is different from the inside and outside the normal ward and bone and joint disease. OK KBD cartilage necrosis of the gene and protein markers, and how environmental factors which Kashin-Beck disease susceptibility gene interactions and selectivity of deep cartilage damage and its intervention measures in the future cause of Kashin-Beck disease pathogenesis of the important goals. [Keywords:] cause of the pathogenesis of Kashin-Beck disease gene Proteomics ABSTRACT: Kashin-Beck disease (KBD) is an endemic and deforming osteochondropathy and its etiology remains unclear up to now. The prevalence of the disease is the severest in the western China and the effective methods for prevention and cure still need further study. This article summarized the progression and problems to be investigated for three main hypotheses of KBD by reviewing literature published at home and abroad. Integrating with his own research work and his team members, the author suggested that excessive apoptosis and dedifferentiation of chondrocytes besides classic chondrocytic necrosis in KBD growth plate and articular cartilage, differences of gene expression profiles in cartilage and peripheral blood mononuclear cells, proteomi