Klotho calcium and phosphorus homeostasis and aging.docVIP

 PAGE \* MERGEFORMAT 14 Klotho calcium and phosphorus homeostasis and aging [Keywords:] aging; Calcium homeostasis; @ Klotho; vitamin D Why aging? The development of how it happened? There is no way to control aging? Human studies for thousands of years old, but these questions remain unanswered .1997 mutant mice in an unexpected discovery @ Klotho gene deletion of the gene lead to calcium, phosphorus concentration, a series of similar aging performance and shortened life expectancy (1). After that knockout fibroblast growth factor (FGF23 gene in mice also have a high calcium, high phosphorus and various aging performance and short-lived (2), and vitamin D receptor knockout (VDR gene in mice is manifested in the concentration of calcium and phosphorus decreased, but the same also appears premature aging and short-lived (3), corrected calcium phosphorus disorders can improve the performance of mutant mice, these abnormalities (4 ~ 7). The study shows that calcium and phosphorus homeostasis and the intrinsic correlation between aging. Since @ Klotho in calcium and phosphorus homeostasis in the central control system, and calcium, phosphorus, FGF23, are closely linked vitamin D, etc., and extend life span in mice (8), so this departure from the @ Klotho and aging of calcium and phosphorus homeostasis we reviewed. 1 @ Klotho gene profile 1.1 Structure @ Klotho gene is located on human chromosome 13q12 (1), about 50 kb, based on the structure suggested that it encodes a type membrane protein (molecular weight of 70 kD, and the extracellular region of the protein structure similar to glucosidase (9, ). However, the actual detected in cells @ Klotho protein (@ Kl mainly exists in two forms in the cytoplasm, a molecular weight of 120 kD, only in the endoplasmic reticulum, and the other a molecular weight of 135 kD, located within the primary Golgi body and the body will be secreted into the extracellular be in the blood, urine, cerebrospinal fluid dete