Knee osteoarthritis etiology and pathogenesis of.docVIP

 PAGE \* MERGEFORMAT 16 Knee osteoarthritis etiology and pathogenesis of Abstract knee osteoarthritis (OA) mainly as a knee joint pain, stiffness, dysfunction, is a clinical orthopedic common and frequently-occurring disease. As China’s population aging intensifies, OA incidence would be further enhanced to study the disease etiology, pathology, and then to find an effective means of combating the disease, is currently the orthopedic community is faced with one of the major issues. 【Key Words】 knee osteoarthritis; etiology; Arthralgia / TCM; Review Knee osteoarthritis is due to a partial knee injury, inflammation or chronic fatigue caused by degeneration of articular cartilage and subchondral bone plate and activities of obstacles chronic, degenerative joint disease [1]. The etiology is mainly by mechanical, biological factors, pathological process is complex, many aspects not yet fully revealed clear, as summarized below. A joint stress imbalance When the joint load, the cartilage deformation, arch along the fiber structure of collagen fibers to withstand the pressure of the direction of conduction, distributed to the subchondral bone, unloading, the pressure disappears, fiber back to the status quo ante, in this process, the cartilage cells remain in the fiber grid to be protected. But when the load conduction disorder, the cartilage matrix of the arch structure will be destroyed, cartilage cells lose the protection role of the damage [2]. 2 protease The present study that, in the role of risk factors, the inflammatory cytokine-mediated articular cartilage and synovial membrane increased expression of various proteases, causing articular cartilage matrix of collagen network and proteoglycan degradation, eventually leading to cartilage degeneration , in this pathological process in the proteasome plays a key role [3]. Collagenase  1 or matrix metalloproteinase (MMP)  1, also known as interstitial collage