Kuijieling particles on the large intestine in patients with ulcerative colitis Toll-like receptors and other indicators of.docVIP

 PAGE \* MERGEFORMAT 13 Kuijieling particles on the large intestine in patients with ulcerative colitis Toll-like receptors and other indicators of Study: New Fan Yawei Chang Dong Huang Ying Zhang Tao Yongsheng Li Zhu east slope of San [Abstract]: Objective To observe the effect of particle Kuijieling with sulfasalazine (SASP) for active ulcerative colitis (UC) of the efficacy of treatment of ulcerative colitis Kuijieling mechanism of particles. Methods of active UC ( large intestine damp-heat syndrome) were randomly divided into treatment group (Kuijieling particles + SASP) and the control group (SASP), observation of TCM syndromes, intestinal mucosal lesions, the main symptom score change. using conventional immunohistochemical SP method detected before and after treatment within the intestinal mucosa Toll-like receptor 4 (TLR4), CD14, nuclear factor-κB p65 (NF-κB p65) protein expression. TCM treatment group effect, higher efficacy of intestinal mucosa (P lt;0.05) .2 group in improving diarrhea, abdominal pain, bloating, pus and blood stools, mucus, tenesmus symptoms after treatment than before treatment were significantly improved (P lt;0.01, P lt;0.05). the treatment group in improving diarrhea, abdominal pain, bloating, tenesmus side effects than the control group was significantly (P lt;0.01, P lt;0.05). TLR4, CD14, NF-κB p65 in the IA values UC between the expression of tumor grade was significantly (P lt;0.01) .2 group after treatment, TLR4, CD14, NF-κB p65 expression was significantly reduced compared with before treatment (P lt;0.01, P lt;0.05) .2 Section TLR4 , CD14 and NF-κB p65 protein expression after treatment there was significant difference between the difference (P lt;0.01, P lt;0.05). Conclusion Kuijieling particles treated with SASP have the exact role of UC, the effect is significant. most likely through inhibiting the expression of TLR4 and CD14 protein, blocking its receptor protein phosphorylation κB activation of the function, an