Lipid ultrasound contrast magnetic Preparation and Experimental Study of image enhancement.docVIP

 PAGE \* MERGEFORMAT 15 Lipid ultrasound contrast magnetic Preparation and Experimental Study of image enhancement [Abstract] Objective: To study the magnetic self-made lipid ultrasound contrast agent in vitro and in vivo the fundamental characteristics of image enhancement effects for the development of both ultrasound manipulation in image enhancement, but also the tumor hyperthermia ultrasound contrast agent provide a theoretical basis and experimental evidence. Methods: (1 by chemical coprecipitation Fe3O4 magnetic nano-materials, mechanical vibration preparing magnetic lipid microbubbles. (2 Malvern particle size measurements of lipid microbubbles was measured magnetic particle size, blood counting board measuring the concentration of SEM and EDS analysis of its morphology and composition. (3 would have been prepared magnetic lipid microbubbles into the original solution at 4 in the store 2 weeks after the change of its shape and size . (4 large color Doppler device to evaluate the imaging results in rabbit liver. (5, respectively, containing different concentrations of magnetic nanoparticles in the lipid microbubbles placed on frequency 230 kHz, the output current of 30 A of the SPG 06A flat high-frequency magnetic induction heating equipment heating coil 1 h, warming observed in vitro. Results: The mean diameter of microbubbles 1 127 nm, the concentration of 3 109ml-1. in 4 refrigerator for 2 weeks, the shape and size did not occur change significantly. The rabbit ear vein into the liver, liver parenchymal echo can be seen clearly enhanced. a certain concentration of magnetic lipid microbubbles with a certain magnetic field characteristics of heating temperature, the temperature can be constant between the 42 ~ 62 . Conclusion : The magnetic properties of lipid microbubbles small particle size, stability, image enhancement effect, the magnetic field with constant heating capacity for future clinical applications for further experimental evidence.