Lithospermum different extracts Experimental Study of anti-inflammatory and antibacterial effects.docVIP

 PAGE \* MERGEFORMAT 2 Lithospermum different extracts Experimental Study of anti-inflammatory and antibacterial effects Authors: Xue-Mei Zhao, Deng, Li Ying, Gui-Ling Wang, Fei Hong-Rong, Zhang Ying, Chen Wei [Abstract] Objective To investigate the Lithospermum different concentrations of ethanol extract and water, put objects inside the anti-inflammatory and antibacterial action in vitro. Methods Kirby-Baue disk diffusion method, determination of Lithospermum different concentrations of ethanol extract and water extract of Staphylococcus aureus, Proteus mirabilis, E. coli, white beads aureus, Pseudomonas aeruginosa, Streptococcus agalactiae , flexneri bacilli inhibitory effect of type Ⅱ . Use of xylene-induced mouse ear swelling method, the Lithospermum different concentrations of ethanol extract and water extract of the anti-inflammatory effect. Results ① compared with the positive control: in a variety of extracts, 80% of the ethanol extract against Staphylococcus aureus, S. flexneri type Ⅱ bacillus, Streptococcus agalactiae to achieve the strongest inhibition, inhibition zone diameters were (11.17 ± 1.26), (10.33 ± 1.54) and (18.67 ± 2.08) mm, in which the inhibition of Streptococcus agalactiae close to the positive control drug erythromycin [erythromycin inhibition zone diameter (19.67 ± 1.52) mm]; 50% ethanol extract and 20% ethanol extract of the antimicrobial effect is relatively weak. Aqueous extract of white beads inhibited bacteria better, bacteriostatic diameter (7.83 ± 0.29) mm; a variety of extracts had no inhibitory effect on E. coli. ② Lithospermum extract anti-inflammatory effect and the concentration of a positive correlation; Lithospermum alcohol extract ZCE-I (containing crude drug 0.06g/ml), ZCE-II (containing crude drug 0.03g/ml) the inhibition rates were 68.91% ( P