Lipid-lowering statins and non-lipid-lowering effect.docVIP

 PAGE \* MERGEFORMAT 11 Lipid-lowering statins and non-lipid-lowering effect Keywords: statin drugs;,, lipid-lowering;,, non-lipid-lowering,,,,, Abstract: In 1976, fungal metabolites from the one proposed in the first statin molecules meuastatiin, marked lipid-lowering drugs statins advent, in order to wither slow sections of atherosclerotic lipids has opened up a new era. In recent years, confirmed that lipid-lowering statins large amplitude, high speed, well tolerated, and has to improve the vascular endothelium, inhibit vascular smooth muscle cell proliferation and migration, reducing cardiovascular and cerebrovascular diseases, the incidence of stroke in patients with anti-platelet aggregation, anti-thrombosis, on the myocardial cells and so on. Keywords: statins; lipid-lowering; non-lipid-lowering From the 50’s, cardiovascular and cerebrovascular diseases gradually replacing infectious diseases became China’s first leading cause of death, including coronary heart disease and stroke mortality increased sharply, has become a very serious health health and social problems. At present, the known hypercholesterolemia, which is addressed to one of the major risk factors for coronary heart disease. To control this situation should be taken to include comprehensive measures, including lifestyle changes, of course, is also an important means of drug intervention. Statins shall be one of the curative effect, safe and reliable lipid-lowering drugs, with a number of large-scale clinical studies in recent years, the completion of its non-lipid-lowering effect and also further attention. Statin drugs are HMGCoA reductase inhibitor drugs is important in vivo rate-limiting enzyme of cholesterol synthesis. Competitive in the liver to inhibit cholesterol biosynthesis, reducing cellular cholesterol content, followed by liver cells caused by low-density lipoprotein (LDL) cholesterol receptors increases, LDL cholesterol clearance rate increa