不同剂量左氧氟沙星治疗下呼吸道感染的成本-效果分析.pdfVIP

·药物经济学· 不同剂量左氧氟沙星治疗下呼吸道感染的成本效果分析 前佩宏飞胡忠杰，黄荣富(武警浙江省总队医院药械科，事兴市 314000) 中图分类略 R978jR956 文献标i只码 C 文章编号 1001一0408(2006)17一 1308-04 摘 要 目的:评价左氧氟i少星不同用药剂量治疗下呼吸道感染的成本一效采，为临床制订合理用药方案提供参考。方法:将 315 例 下呼吸道感染患者随机分为 3 组，分别应用左轧氟沙2l 900mg(A 组)、60加19(日组)、30Omg(C 纽)进行治疗，观察1)各床疗效，并进行 成本…效果分析。结果 :3 纽总有效率分别为 87.62% 、 84.76% 、 79.05% ，细菌清除率分别为 94.38% 、 90.80% 、 81. 32% ，不良反应 发生率分别为队67% 、 4.76% 、3.81%; 治疗成本分别为 1116.75、997.82 、 826.46 元;成本一效采比分别为 12.74、 11.77、1O.45;A 、 B 组相对于 C 组的增量成本 效采比分别为 33.87、30.01。结论:应用 600 mg 左氧氟沙皇进行治疗是比较合理的用药方棠。 关键词 在轧氟沙里;不同费IJ爱;下呼吸遥感染;成本…效果分析 Cost - effectiveness Analysis of LevofIoxacin at Different Dose for Lower Respiratory Tract Infections MIAO Peihong , HU Zhongjie , HUANG Rongfu(Dept.of Pharmacy , Zhejiang Provincial Corps Hospital of Chinese People s Armed Police Forc巳s ，Jiaxing 314000 , China) ABSTRACT OB]ECTIVE: To evaluate the cost - effectiven巳ss of levof1oxacin at different dosa反e for lower respiratory tract infections so as to guide a rational drug use in the clinic. METHODS: 315 patients with lower tract infections were randomly assigned to receive levofloxacin at different dosage: 900mg (group A) , 600mg(group B) or 300mg(group C) , clìnical efficacìes were observed and cost - effectiveness analysis was performed. RESULTS: The total eHective rates of the 3 group日 were 87.62% , 84.76% and 79.05% , respectively , the germ - clearance rates were 94.38% , 90.80% and 81.32% , respectively , the incidences of adverse effects were 6.67% , 4.76% and 3.81 %, respectively; The treatment costs of 3 groups were 1116.75 yuan , 997.82 yuan and 826.46 yuan , respectìvely; The cost … effectìveness ratìos were 12.74, 11 嗣 77 and 10.45. respectively; Th日 incre­ mental cost - effectiveness ratios of group A and B were 33.87 and 30.01 respectively as against group C. CONCLUSION: Lev- ofloxacìn at a dosage of 600mg is the optimal one for lower respiratory tract infections. KEY WORDS Levofloxacin;Difference dosage;Lower r巳spiratory tract infections;Cost - effe