MCP1 and VEGF expression in ovarian cancer and its clinical significance.doc

 PAGE \* MERGEFORMAT 8 MCP1 and VEGF expression in ovarian cancer and its clinical significance Of: Zhang Wei Sun Yingchun Chen Pingmei Ji Hui Qing Zheng Lizhong, red-step [Abstract] Objective To investigate the ovarian cancer (OCa) and normal ovarian tissue monocyte chemoattractant protein (MCP) 1 and vascular endothelial growth factor (VEGF) expression and clinical significance. Methods Immunohistochemical staining OCa pelvic tissues and OCa metastasis, benign epithelial ovarian disease, benign tumor and tissue MCP 1, VEGF expression, analyzed the relationship between biological characteristics and OCa. The results MCP 1 and metastasis in OCa positive rate was significantly higher than the normal benign ovarian tissue and ovarian (P lt;0.05); VEGF positive rate in the OCa significantly higher than in normal ovarian tissue and benign ovarian tumors (P lt;0.05). Conclusions MCP 1 and VEGF expression was significantly increased in OCa with OCa angiogenesis and invasion, metastasis, may be OCa play an important role in occurrence and development. [Keywords:] ovarian cancer; monocyte chemoattractant protein 1; of Vascular Endothelial Growth Factor Monocyte chemoattractant protein 1 (MCP 1) by promoting the aggregation of macrophages on tumor growth and promoted the transfer of (1). Studies have shown that overexpression of MCP 1 tumor infiltration of mononuclear cells induced by vascular endothelial growth factor for (VEGF) expression and promote tumor angiogenesis, VEGF can increase the permeability of new blood vessels to help cancer cells into the bloodstream and to other organizations to facilitate the transfer of tumor (2,3). This study used immunohistochemistry method Detection of MCP 1, and VEGF protein in ovarian cancer (OCa) tissues and its relationship with clinical pathological features OCa for MCP 1 and VEGF for clinical and pathological diagnosis of experimental evidence. 1 Materials and methods Collection of specimen collection 1.1