Metastasis Ezrin proteins role in cancer research progress.docVIP

 PAGE \* MERGEFORMAT 22 Metastasis Ezrin protein’s role in cancer research progress [Keywords:] cancer Ezrin protein Transfer is recognized as the world leading cause of death in patients with malignant tumors, about 90% of patients died of malignant tumor metastasis [1]. Metastasis from Stephen Paget proposed the seeds of soil science that has, for the mechanism of tumor metastasis has been a hundred years history, with the gene under the control of tumor metastasis, multi-stage, multi-factor, multi-step theory of continuous improvement, people metastasis of this very complex understanding of the pathological process has been further found and confirmed a high correlation with tumor metastasis genes, mechanisms of tumor metastasis has now become a hot research field, because these genes will not only enable us to better understand the mechanism of tumor metastasis, and more importantly, its gene product may become target of anti-tumor or the tumor metastasis prognosis and metastasis of the index. Many scientists Ezrin protein coding genes and their expression in malignant tumors lot of research, has yielded a large number of results, but there are some inadequacies, are summarized below. 1 Ezrin protein gene mapping The gene encoding Ezrin is villin2, located on chromosome 6q25.2 q26, belongs to ERM family members, the family includes: Ezrin, Redixin, Moesin, Merlin4 kinds of proteins with similar structures, respectively, in cells play a role in a variety of activities. Ezrin is Bretscher in 1981 by the chicken brush border of intestinal epithelial cells were purified for the first time, while the other three members of the ERM family Radixin, Moesin, and Merlin, respectively in 1988,1989 and 1993 were identified. 2 Ezrin protein structure and function Ezrin (also known as: Ezra ERM family of proteins as the first member is found, its structure and function is relatively the most thoroughly studied. Ezrin protein in the N terminal has a