Methylprednisolone use in spinal surgery.doc

 PAGE \* MERGEFORMAT 11 Methylprednisolone use in spinal surgery [Keywords:] spinal cord injury / treatment of methylprednisolone Patients in the treatment of spinal surgery, nerve injury more common in patients, some patients damage to the critical state in the spinal cord or nerve damage has occurred, surgical treatment of vibration, traction, implant placement may result in irritation or operation spinal cord edema, ischemia, or nerve conduction disturbances arise or worsen nerve damage. acute spinal cord injury in addition to the primary injury, but also with the microcirculation, lipid peroxidation, calcium channel disorders and the release of endorphins and other secondary prejudice. restoration of blood flow after decompression of spinal cord caused by spinal cord injury, spinal cord injury and white matter, gray matter neurons in the region of nerve conduction fibers of the response is not consistent with external force, the white matter of direct external force stronger than the gray matter nerve tolerance dollars, but secondary damage to white matter fiber conduction greater impact, so if you can minimize secondary spinal cord injury, site of injury and white matter neurons conductive fiber function would be preserved, the range of spinal cord injury will effective control [1]. 6h after injury in the spinal cord gray matter necrosis, white matter after injury, 8 ~ 12h in necrosis, self-destruction if the process of blocking the spinal cord, preserving the function of the spinal cord white matter to the reservation can maximize residual limb nerve function. Some studies have shown [2], through drug intervention lesion spinal cord injury can play a relieve spinal cord injury and improve neurological function in the role of high-dose methylprednisolone treatment of acute spinal cord injury in the international has been recognized. 1 methylprednisolone use in spinal surgery Early and appropriate application of spinal cord injury with methylp