Metoprolol in the treatment of chronic heart failure 36 cases.docVIP

 PAGE \* MERGEFORMAT 5 Metoprolol in the treatment of chronic heart failure 36 cases [Keywords:] Heart failure; metoprolol; -blocker In recent years, metoprolol treatment of chronic heart failure (CHF) and 36 patients with clinical base. Were observed, are as follows. 1 Clinical data 1.1 General Information January 2005 ~ June 2008 due to structural heart disease complicated by CHF patient received conventional diuretics, cardiac glycosides 2 weeks of treatment no significant improvement in cardiac function in refractory CHF 72 patients, male 46 cases, 26 females, aged 35 to 76 years, mean age 56.6 years. 42 cases of coronary heart disease, dilated cardiomyopathy in 26 cases, 4 cases of rheumatic heart disease. NYHA classification of cardiac function were . blood, urine, liver , renal function, electrolyte tests were normal, the clinical use of -blockers were no contraindications. randomly divided into treatment group and control group of 36 patients, 2 groups of gender, age, concomitant risk factors (smoking, hypertension , diabetes, hyperlipidemia) and conventional medical treatment was no significant difference (Pgt; 0.05). 1.2 treatment control group: given digitalis, diuretics, vasodilators, angiotensin converting enzyme inhibitor (ACEI) conventional treatment; treatment groups: conventional therapy, and with the -blocker (U.S. metoprolol), the initial dose of 6.25 mg, 2 times / d, 2 weeks later increased to 12.5 mg, 2 times / d. before treatment and after 10 weeks, and clinical manifestations (including chest tightness, shortness of breath, lung wet rales, lower extremity edema, and adverse reactions, etc.), measurement of blood pressure (BP), heart rate (HR), determination of liver and kidney function, blood lipids, electrolytes, chest X-ray film, and for ECG, echocardiography, left ventricular fractional shortening (D), cardiac index (CI), diastolic mitral E peak and A peak ratio (E / A), X ray test cardiothoracic ratio (C / T). 1.3 SP