Metoprolol on isoproterenol rat model of congestive heart failure of TNF.doc

 PAGE \* MERGEFORMAT 16 Metoprolol on isoproterenol rat model of congestive heart failure of TNF Of: Cai Hui, Guo Han, Zhao Zhiming, Cai Jiayu Guo Hao County [Abstract] Objective of metoprolol on congestive heart failure (HF) plasma tumor necrosis factor - @ (TNF-@). Methods 80 male SD rats were randomly divided into control group (n = 10) and model group (n = 70), model group, the subcutaneous injection of isoproterenol 2 (170 mg kg-1), 6 weeks after the application of echocardiography to determine left ventricular ejection fraction 45% the modeling, the rat model of heart failure, heart failure were randomly divided into control group (n = 13), metoprolol group (n = 14); 18 weeks after the use of left heart catheterization for hemodynamic examination, the use of radioimmunoassay plasma TNF-@ pathological changes in cardiac morphology were observed. Results compared with the control group, heart failure group was significantly worse heart function, ventricular mass index, left ventricular mass index and plasma TNF-@ was significantly higher (P lt; 0.01), significant ventricular remodeling; control group with heart failure, metoprolol significantly improved heart function, ventricular mass index, left ventricular mass index and plasma TNF-@ was significantly lower (P lt;0.05), ventricular remodeling better. Conclusion Metoprolol can improve heart function, reverse ventricular remodeling, whose heart failure in rats by inhibiting the expression of plasma TNF-@. [Keywords:] congestive heart failure; isoproterenol; metoprolol; rat; tumor necrosis factor - @; ventricular remodeling Abstract: Objective To explore the effect of metoprolol on plasma tumour necrosis factor-@ (TNF-@) in rats with congestive heart failure (CHF). Methods 80 male SD rats were randomly allocated to the isoproterenol (ISO)-induced heart failure group (n = 70) receiving a subcutaneous injection of ISO (170 mg per kilogram of body weight) twice and the healthy normal group (n =