Microbial metabolic products in the application of thrombolytic drugs.doc

 PAGE \* MERGEFORMAT 12 Microbial metabolic products in the application of thrombolytic drugs Author: Koo turn-wing, Pan Jie, Cheng distance, Bei Wang Keywords: microbial metabolites;,, thrombolytic drugs;,, kinase;,,,, fibrinolytic activity With the development of basic life sciences and a variety of new bio-technology, produced by micro-organisms that have addition to anti-infective, anti-tumor effect other than the increasing number of reports of active substances, such as enzymes, immune modulators, receptor antagonist agents and oxidants such as, in the microbial agents under study in recent years, thrombolytic drugs are another major attraction. Current thrombosis [such as acute myocardial infarction (AMI), venous thrombosis, etc.] has become a serious harm to human health and life of cardiovascular disease, according to the WHO survey, the world’s disease in patients with blood plug not less than 1 5 million people [1] so, on the majority of older persons. Cardio-cerebral vascular diseases has leapt to the human cause of death in the first place, the development of high-specific thrombolytic drugs in the fight against cardiovascular and cerebrovascular diseases, an important means, so thrombolytic drug research and development is also very active. Because microbial growth speed and easy to control growth conditions, the product extraction process is also relatively simple, and therefore microbes as thrombolytic drugs (fibrinolytic active substance) is an important source of more and more attention. 1 micro-organisms in drug research in the important position of Microbial drugs that possess anti-microbial effect and other physiological activity of microbial secondary metabolites and its derivatives. 1929, British bacteriologist A. Fleming discovered the first one with practical significance of antibiotics - penicillin, in the great medical benefits, under the facilitation of micro-biologists States set off an extensive search