Microemulsion matrine on mouse liver injury model of carbon tetrachloride.docVIP

 PAGE \* MERGEFORMAT 9 Microemulsion matrine on mouse liver injury model of carbon tetrachloride [Abstract] Objective To investigate the carbon tetrachloride in mice microemulsion matrine (CCl4) liver injury model in rats. Methods CCl4 model of acute liver injury in mice, preventive microemulsion through the skin to the matrine high, medium and low dose (200,100,50 mg / kg) and fed to the matrine aqueous solution (200 mg / kg), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) . The results with the CCl4 group, emulsion and high dose of oral solution group and matrine, ALT were significantly lower, and matrine high dose oral microemulsion solution group, AST was significantly decreased, matrine microemulsion Group ALT, AST levels and oral administration of matrine aqueous solution was no significant difference between groups. Conclusion microemulsion matrine on acute CCl4 liver injury down aminotransferase role, with some prospects for new drug development. [Keywords:] matrine; microemulsion; transdermal drug delivery; CCl4 liver injury Abstract: ObjectiveTo investigate the protective effects of matrine microemulsion on mouse model of liver injury induced by carbon tetrachloride. MethodsThe mouse model of liver injury was induced by CCl4. The matrine microemulsion by transdermal delivery in high, medium and low-dose (200, 100 , 50 mg / kg), and water solution of matrine by oral administration (gavage control 200 mg / kg), and the activities of alanine transferase (ALT) and aspartate amino transferase (AST) in serum were determined.ResultsCompared with CCl4 group, ALT was significantly decrcased in the groups of high and medium doses of the matrine microemulsion and the group of water solution of matrine, and the AST was significantly reduced in the group of high doses of the matrine microemulsion and the group of water solution of matrine. The ALT and AST levels were no significantly different between the two groups of matrine micr