Miltiorrhiza on prevention of stress ulcer in young rats in the experimental study the mechanism.doc

 PAGE \* MERGEFORMAT 21 Miltiorrhiza on prevention of stress ulcer in young rats in the experimental study the mechanism [Abstract] Objective: To investigate the Danshen injection on stress ulcer in young rats (SU mucosa and the possible mechanisms of injury prevention. METHODS: 36 young rats were randomly divided into 6 groups, normal control group, stress group 3 h ( group, stress before the intraperitoneal injection of saline 2 mL + 3 h stress group ( group, intraperitoneal injection before stress stress Salvia 2 + 3 h group ( group, intraperitoneal injection before stress should Salvia 4 + 3 h stimulated group ( group, intraperitoneal injection before stress stress Salvia 6 + 3 h group ( group, produced by immersion restraint stress ulcer in animal models, to detect the gastric ulcer index (UI, stomach mucosal blood flow (GMBF and gastric tissue superoxide dismutase (SOD activity and malondialdehyde (MDA, tumor necrosis factor (TNF @ content. Results: (1 Salvia can significantly reduce the damage model in the UI, (2 RSM rats significantly reduced MDA content in gastric tissue and serum, increase SOD activity in gastric tissue and serum, (3 Salvia rats gastric mucosa can reduce the level of TNF @. , , group were lower than TNF @ group, and descending order, group compared with significantly (P lt;0.05. Conclusion: Salvia miltiorrhiza on prevention of stress ulcer with its mechanisms and improve the gastric microcirculation, antioxidant and free radical scavenging by mononuclear macrophages secreted TNF @ in regulation, and effects. [Keywords:] Salvia, stress, gastric, ulcer, free radicals, tumor necrosis factor [Abstract] Objective: To investigate the prophylactic effect of Radix Salvia Miltiorrhiae Injection (RSM) on acute gastric mucosal injury and to explore possible mechanism in young rats.Methods: Thirty six SD young rats were randomly divided into six groups. Different times of RSM (2 times, 4 times and 6 times per rat before gastric mucos