MMP -7 and tissue inhibitor of metalloproteinase -1 in bladder transitional cell carcinoma and its significance.doc

 PAGE \* MERGEFORMAT 12 MMP -7 and tissue inhibitor of metalloproteinase -1 in bladder transitional cell carcinoma and its significance Study: LI Wen-lin, Duan Jianmin, Ma Guangxu, Xuchong Wei, Ding Rui Zhi [Abstract] Objective To study matrix metalloproteinase -7 (MMP-7 and tissue inhibitor of metalloproteinase -1 (TIMP-1 in bladder transitional cell carcinoma and its significance. Methods Immunohistochemical staining detected in 60 cases of bladder transitional cell carcinoma [ level in 25 cases, grade 15 cases, grade, 20 cases of superficial bladder cancer (Tis ~ T129 cases, invasive (T2 ~ T431 cases] and 5 normal bladder tissue MMP-7 and TIMP-1 in expression, 2 test to analyze the expression and grading and staging of bladder cancer. Results MMP-7 and TIMP-1 in normal bladder tissue was not expressed, whereas in bladder transitional cell carcinoma of the bladder tissue strong .60 specimens of transitional cell carcinoma of MMP-7 expression in 40 cases (66.7%. MMP-7 positive expression rate of pathological grade was significantly correlated with the clinical stage was no significant correlation with 60 cases of bladder transitional cell carcinoma specimens of TIMP-1 expression in 32 cases (53.3%. TIMP-1 in different histological differentiation between the different clinical stages were no significant differences (Pgt; 0.05. The ratio of MMP-7/TIMP-1 expression with the pathological grade was significantly correlated. Conclusion MMP-7 and the MMP-7/TIMP-1 ratio may reflect the malignant bladder transitional cell carcinoma of the degree of bladder transitional cell carcinoma of the prognosis of a new reference index. [Keywords:] bladder cancer, cancer, metalloproteinases, tissue inhibitor of metalloproteinase [Abstract] Objective To evaluate the expression of matrix metalloproteinase-7 (MMP-7and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1in transitional cell carcinoma of bladder (TCCBand its significance.Methods Immunohistochemistry w