MMP-2 MMP-9 and cerebral hemorrhage Progress_0.doc

 PAGE \* MERGEFORMAT 19 MMP-2 MMP-9 and cerebral hemorrhage Progress [Keywords:] cerebral hemorrhage; MMP-2; MMP-9; cerebral edema MMP (Matrix metalloproteinases, MMPs) are a group activity of homologous calcium and zinc dependent neutral protease gene family, is widely involved in the degradation of various extracellular matrix of the body (ECM) of the protease, is found 20 kinds, including MMP-2 and MMP-9 are the two most important MMPs family members. Because MMP-2 and MMP-9 role in the degradation of extracellular matrix of normal balance is upset, leading to a variety of pathological processes occurrence, such as demyelination, blood-brain barrier damage. Recent studies suggest that MMP-2 and MMP-9 and cerebral vascular disease is closely related to their participation in a cerebral hemorrhage and brain edema and secondary brain inflammation injury in the pathological process and play an important role. This article focuses on the relationship between cerebral hemorrhage and its research progress and briefly reviewed. 1 MMP-2 and MMP-9 and regulation characteristics MMP was first in 1962, Gross and Lapiere metamorphosis of tadpole tail was found. At present at least 21 MMPs have been found series of enzymes, the main functions of these enzymes break down extracellular matrix, in normal human embryonic development, tissue remodeling , scar transformation and angiogenesis, wound healing plays an important role, and abnormal expression of MMPs is also involved in starting a number of human pathophysiological processes, such as tumor invasion and metastasis, inflammation, the formation of atherosclerosis, vascular regeneration and so on. 1.1 MMP-2 and MMP-9 MMP-2 which features 72 KD IV collagenase (also known as gelatinase A, matrixmetalloproteinases-2, MMP-2), it is Liotta [1] for the first time in the highly metastatic mouse transplanted tumor found in the culture medium in a neutral metalloproteinase, present in many cancer cell culture medi