Mouse embryonic stem cell self-renewal signal control mechanism.doc

 PAGE \* MERGEFORMAT 28 Mouse embryonic stem cell self-renewal signal control mechanism Abstract mouse embryonic stem cells are a totipotent cell, with the all-around vivo and in vitro differentiation characteristics. When cultured in vitro to carry out self-renewing, ie cell division through the symmetry is not lost in the maintenance of totipotent cells, increased number of cases. Totipotency maintained by the regulation of multiple signaling pathways, including gp130 downstream JAK-STAT3 and PI3K pathway activation energy of the maintenance of embryonic stem cell self-renewal, while the SHP2-Ras-ERK activation is to promote embryonic stem cell differentiation. Under serum-free conditions, BMP4 activation of JAK-STAT3 pathway and the combined effects may remain totipotent embryonic stem cells. In addition, Wnt signaling pathway are also involved in the activation of the embryonic stem cell self-renewal of regulation. In short, a variety of signaling pathways of a network of precise regulation of mouse embryonic stem cells self-renewal and differentiation. In this paper, overview of gp130 in mice, the role of ES cell proliferation, including activation of JAK-STAT3 pathway inhibited differentiation of mouse ES cells, PI3K pathway activation to maintain ES cell self-renewal and SHP-2-Ras pathway activation to promote ES cell differentiation, as well as other signaling pathway on mouse ES cell self-renewal, including serum-free conditions, BMP co-LIF to maintain a high degree of ES cell self-renewal, Wnt signaling pathway activation to promote ES cell self-renewal. Keywords: embryonic stem cell self-renewal signaling pathway totipotent Signaling Pathways Regulating Self-renewal of Mouse Embryonic Stem Cells - Review AbstractMouse embryonic stem cells (ES cells) are pluripotent in that they can give rise to almost all the cell types in vitro and in vivo. Also, they can sustain self-renewal in vitro owing to symmetrical mitosis, ie, only t