Monitoring of serum leptin in patients with chronic liver disease and its clinical significance level.doc

 PAGE \* MERGEFORMAT 10 Monitoring of serum leptin in patients with chronic liver disease and its clinical significance level [Abstract] Objective monitoring of serum leptin levels in patients with chronic liver disease to investigate the pathogenesis of liver fibrosis in significance. Methods Using enzyme-linked radioimmunoassay in 30 patients with chronic liver disease patients and 30 controls, serum leptin and liver fibrosis serum markers: hyaluronic acid (HA), collagen (-C) and laminin (LN) level and a liver biopsy. Results of chronic liver disease and serum leptin levels in patients with HA, -C , LN were significantly higher (P lt;0.01, and leptin levels and Child-Pugh grading (P lt;0.01, and HA, -C, LN was positively correlated (P lt;0.01. Conclusions Patients with chronic liver disease liver fibrosis, serum leptin levels also increased significantly, which may be related to the degree of development of liver fibrosis. [Keywords:] leptin and liver fibrosis in chronic liver disease Leptin was initially thought to be a secreted by fat cells and can lead to reduced food intake, suppress appetite, increase energy metabolism of sex hormones. In recent years found that endocrine regulation and energy metabolism of fat-derived important peptide hormones, a wide range of biological effects. clinical study showed that leptin was not expressed in normal liver tissues, but stimulation of pathological factors, leptin was significantly increased in liver fibrosis, the development process, play an important role in leptin , suggesting that leptin is closely related with liver fibrosis. Therefore, further observation of serum leptin levels in patients with chronic liver disease and liver fibrosis, chronic liver disease and serum leptin levels in patients with Child-Pugh classification, serum markers of liver fibrosis such relations, the understanding of leptin’s role in liver fibrosis is important. 1 Materials and Methods 1.1 General information