Mongolians in patients with coronary heart endothelial nitric oxide synthase gene G894T polymorphism.doc

 PAGE \* MERGEFORMAT 9 Mongolians in patients with coronary heart endothelial nitric oxide synthase gene G894T polymorphism Of: Feng Xiuli Yang Zhongwei Jiangxue Ping Xiao Bai [Abstract] the crowd of Mongolians Objective Endothelial Nitric Oxide Synthase (eNOS) gene polymorphism and coronary heart disease. Methods of polymerase chain reaction restriction fragment length polymorphism analysis (PCR RFLP), detection of Mongolians in 82 normal individuals and 86 patients with coronary heart disease eNOS gene G894T polymorphism. Results Mongolian normal individuals and patients with coronary heart disease gene G894T polymorphism of eNOS GG, GT, TT genotype frequencies were 0.80, 0.16,0.04 and 0.81,0.07,0.12, G and T allele frequencies were 0.88,0.12 and 0.85,0.15, coronary heart disease patients with genotypes decreased GT, TT genotype frequency increased, but the difference was not significant (2 = 3.637 9, Pgt; 0.05). Conclusion eNOS gene G894T polymorphism and coronary heart disease Mongolians, but needs further study. [Keywords:] Coronary heart disease; Mongolian; endothelial nitric oxide synthase gene; gene polymorphism Coronary heart disease is the interaction of genetic and environmental factors due to the complexity of disease pathogenesis and between multiple genes and gene environment interactions and other relevant. At present, some scholars believe may be several genes associated with coronary heart disease, These genes play a single or in combination, may also be shared with the traditional role of predisposing factors increased the risk of coronary heart disease. We polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) detected 82 cases of Mongolia, Xinjiang normal individuals and 86 family cases of CHD endothelial nitric oxide synthase (eNOS) gene G894T mutation of the situation. 1 Materials and methods 1.1 The study randomly selected 168 cases in Xinjiang Mongolian unrelated normal population and Mongolia