Moxifloxacin hydrochloride eardrops Preparation and Quality Control.doc

 PAGE \* MERGEFORMAT 12 Moxifloxacin hydrochloride eardrops Preparation and Quality Control Author: Du Xi-Chi Xi-Kui Rui-Min Li Hongyan Li Jinwei Dr Tan Yi \ 【Abstract】 Objective: Preparation of Moxifloxacin hydrochloride eardrops to establish its quality control methods. Methods: The main high-performance liquid chromatography Moxifloxacin hydrochloride content, and examine its stability. Results: Moxifloxacin hydrochloride linear range of 0.4μg ~ 3μg, the average recovery was 97  67%, RSD = 1.75% (n = 6), Ear Drops good stability. Conclusion: The design is reasonable, accurate and reliable method of quality control, preparation and good stability. Keywords: Moxifloxacin hydrochloride; Ear Drops; preparation; Quality Control In recent years, chronic ear inflammation diffuse upward trend in the incidence of clinical bacterial culture results showed that the inflammation caused by bacterial infection [1]. Moxifloxacin (moxifolxacin) for Bayer’s newly developed 4th generation of new, ultra-broad-spectrum quinolone antibacterial agents [2], it is good to keep the traditional quinolone resistant Gram-negative bacteria based on the in vitro activity of anti-Ge the activity of Gram-positive bacteria has been enhanced [3], of this product-resistant Gram-positive bacteria resistant produce little or very slow. Pairs of aerobic Gram-positive cocci in vitro antibacterial activity of ciprofloxacin stronger than the 4 to 8 times. Currently on the market already tablets, injections, we prepared the basis of clinical need Moxifloxacin hydrochloride eardrops and the establishment of quality control methods. An instrument and reagent Shimadzu LC  10AD-based high-performance liquid chromatography (including the SPD  10A UV detector, SC1  10A controller, C  RTA-based chromatographic data processor); 7312  1 Electric mixer (Beijing Poor Analysis of General Instrument Co., Ltd.); PHB  1 Portable pH meter (TriTrust companies). Mo