Nanoemulsion capsaicin injection of hemolytic and vascular irritation test.doc

 PAGE \* MERGEFORMAT 7 Nanoemulsion capsaicin injection of hemolytic and vascular irritation test [Abstract] Objective nanoemulsion capsaicin injection for evaluation of hemolytic and vascular stimulation. Methods of rabbits in vitro hemolysis test and vascular irritation test in rabbits. Results of 0.004% capsaicin injection nanoemulsion is no hemolysis, and 3 h No red blood cell agglutination by 20 g / kg rabbit ear vein injection of non-vascular stimulation. Conclusion of effective dose of capsaicin injection nanoemulsion no hemolysis and vascular irritation, provide reference for further research. [Keywords:] Capsaicin; nanoemulsion; injection; hemolytic; vascular stimulation Abstract: Objective To evaluate the hemolysis and vascular irritation of nanoemulsion Injection of capsaicin.Methods Experiments including in vitro hemolytic test in rabbits and in vivo vascular irritation test in rabbits were carried out.Results Hemolysis and erythrocyte agglutination were not observed in in vitro test after adding 0.004% capsaicin nanoemulsion for 3 hours. Vascular irritation in rabbits was not observed also after intravenous administration of the preparation at the dosage of 20 g / kg.Conclusion There was no hemolysis and vascular irritation reactions concerned with nanoemulsion injection of capsaicin at the effective dosage in rabbits. Keywords:: capsaicin; nanoemulsion; injection; hemolysis; vascular irritation Capsaicin (capsaicin) [1] is material and has a spicy chili major component of drug activity, through the selective antagonist of neuropeptide substance P exert anti-inflammatory analgesic effect [2], can be effective in treating postherpetic neuralgia, diabetic neuropathic pain, rheumatoid arthritis and osteoarthritis, pain, is a new non-addictive anti-inflammatory analgesic drugs [3]. As is effective and the United States Pharmacopoeia began to collect the set from the 24 version. nanoemulsion is made to capsaicin injection, to achieve rapi