Myocardial protective effect of isoflurane mechanisms and clinical application.doc

 PAGE \* MERGEFORMAT 19 Myocardial protective effect of isoflurane mechanisms and clinical application [Abstract] an increasing number of basic and clinical studies have shown that isoflurane can significantly reduce the myocardial ischemia / reperfusion injury, this protective effect mainly in the isoflurane preconditioning ischemia and reperfusion and post-processing ways. There are a variety of its mechanism of action doctrine, including: a variety of media interaction triggers the body to activate multiple signal transduction systems such as protein kinase (PKC) pathway, nitric acid casein protein kinase (PTK) pathway and mitogen-activated protein kinase ( MAPKs) pathways, so that the cells produce a variety of protective effector such as activation of adenosine receptors, opening of mitochondrial ATP-sensitive potassium channels in the membrane surface, decreasing the intracellular Ca2 + overload, increased myocardial ATP synthesis and storage, inhibit accumulation of oxygen free radicals, increase in BCL 2 expression and inhibit the release of inflammatory factors and so on. The study also showed that isoflurane’s myocardial protection after a certain clinical application. [Keywords:] isoflurane ischemic preconditioning in myocardial protection after treatment Clinical anesthesia with isoflurane is a commonly used inhaled (volatile anesthetic agents, but a lot of evidence that myocardial ischemia and reperfusion before and immediately after inhalation of the drug can significantly reduce myocardial ischemia-reperfusion injury, and its mechanism complex, is unknown. addition, although clinical application has good prospects, but few clinical studies. In this paper, reported in the literature are summarized below. 1 isoflurane preconditioning (IPC and mechanism of myocardial protection Numerous studies show that isoflurane preconditioning on myocardial protection has obvious, but the mechanism has not been elucidated, studies have shown the f