Myocardium of diabetic rats with platelet-derived growth factorB expression and cardiac fibrosis.doc

 PAGE \* MERGEFORMAT 13 Myocardium of diabetic rats with platelet-derived growth factorB expression and cardiac fibrosis [Abstract] Objective of diabetic (DM) rats with myocardial platelet-derived growth factor B (PDGF B expression and myocardial fibrosis. Methods 32 rats were divided into control group, DM untreated group, valsartan low-dose treatment group (10 mg kg-1 d-1, high-dose valsartan treatment group (30 mg kg-1 d 1,12 w measured by radioimmunoassay after plasma and myocardial angiotensin (Ang concentration , weighed and the heart, left ventricular weight, heart weight ratio calculated (H / B and left ventricular mass index (LVMI, Sirius red staining measurements of myocardial interstitial collagen volume fraction (CVF. RT PCR to detect the cardiac PDGF B , fibronectin (FN, collagen (Col of mRNA expression. Results DM untreated group H / B, LVMI increased (P lt;0.01), PDGF B, FN and Col mRNA expression was significantly increased, valsartan 12 w, plasma and myocardial Ang concentration, H / B, LVMI decreased (P lt;0.05 or P lt;0.01, DM myocardium of FN, Col mRNA expression is reduced, myocardial interstitial CVF decreased (all P lt;0.01, the size of dose group can reduce the DM expression of cardiac PDGF B mRNA (P lt;0.01. These effects in a dose dependent manner. CONCLUSION DM myocardial PDGF B expression was significantly up-regulated. valsartan can reduce DM myocardial extracellular matrix (ECM) accumulation to improve myocardial structure, PDGF B expression may be Valsartan reduced cardiac fibrosis in the heart of DM inhibition of protection mechanisms. [Keywords:] Valsartan, diabetes, rats, cardiomyopathy, platelet derived growth factor B 1 The First Affiliated Hospital of Fujian Medical University, Department of Endocrinology, Myocardial fibrosis in diabetic cardiomyopathy (DC) important pathological changes in diabetes mellitus (DM) diastolic dysfunction, congestive heart failure occurs and then one of the main (1). Plate