Natural regulatory T cells and autoimmune diseases.doc

 PAGE \* MERGEFORMAT 19 Natural regulatory T cells and autoimmune diseases [Keywords:] regulatory T cells; autoimmune disease; immune regulation Regulatory T cells (regulatory T cells, Treg are a class of low proliferative capacity, can inhibit the immune response of cells in the immune pathology, transplantation tolerance and prevent autoimmune response and the maintenance of immune balance play an important effect. In recent years, regulatory T cells has become a hot research field of immunology, has now been confirmed in addition to CD4 + Treg, the part of the CD8 + T cells, CD4-CD8-T cells, NKT cells also have similar immune function. this focuses on the CD4 + CD25 + T cells is the first report of regulatory T cells, these cells were healthy individuals, CD4 + lymphocytes in peripheral 5% to 10%. Since 1995, Sakaguchi et al [1] first reported CD4 + CD25 + regulator Since T-cells, where they are produced, development, differentiation, maturation, function and relationship with various autoimmune diseases, had undertaken extensive research, is briefly summarized below them. 1 regulatory T cells classification, feature Currently considered, Treg including Tr1, Th3 and CD4 + CD25 + Treg. According to different sources can be divided into natural and adaptive Treg Treg. Inherent Treg also known as natural Treg (natural Treg, are those that mature in the thymus into the periphery after lymphoid tissue of Treg, in the prevention of pathological autoimmune responses play a role, adaptive Treg that is acquired Treg, mature T cells from induced, involved in controlling microbial infections and immune responses in transplantation. natural Treg cell inhibition mechanism is Contact-dependent and cytokine-independent, and access to the inhibition mechanism of Treg is not dependent on cell contacts but on the role of cytokines [2]. cytokines dependent mainly through the secretion of interleukin 10 (IL 10, transforming growth factor (TGF effector cells such