Naoxintong capsule on rat model of vascular dementia therapeutic effect of.docVIP

 PAGE \* MERGEFORMAT 6 Naoxintong capsule on rat model of vascular dementia therapeutic effect of [Keywords:] Naoxintong capsules;,, middle cerebral artery occlusion;,, vascular dementia;,, learning and memory;,, hippocampus Abstract: Objective To observe the Naoxintong Capsule on vascular dementia rat model behavior and morphology of the role of the hippocampus. Methods The middle cerebral artery occlusion method (MCAO) produced animal models of vascular dementia; step down test measured learning and memory in rats; take brain tissue for frozen section, HE staining to observe morphological changes in rat hippocampus. Results jumping experiments, compared with the sham-operated group, model group, there is a clear learning and memory disorders; with the model group, Naoxintong capsules, Hydergine two treatment groups improved learning and memory abilities in rats, and the two groups was no significant difference. Light microscopy showed that sham-operated rats hippocampal CA1 pyramidal cells closely arranged neatly, no significant neuron loss; model hippocampal CA1 pyramidal cells, sparsely arranged, disorder marked neuron loss, we can see plastic Leydig cell hyperplasia, in western medicine treatment group can significantly reduce the CA1 area of rat hippocampal neuron loss phenomenon, pyramidal cell morphology compared with normal, arranged more neatly, close to sham-operated group. Conclusion Naoxintong Capsule on vascular dementia model rats have therapeutic effects. Keywords:: Brain and Heart Capsule; middle cerebral artery occlusion; vascular dementia; learning and memory; hippocampus Therapeutic Effects of Naoxintong Capsule on Rats Model of Vascular Dementia Abstract: ObjectiveTo study the effects of Naoxintong capsule on behavior and hippocampal histomorphology in vascular dementia rats.MethodsThe vascular dementia model was established by occlusion of the middle cerebral artery in rats. The faculty of learning and memory were evaluated by stepdow