Myrobalan extracts and drug-containing serum on rat liver cell injury research.docVIP

 PAGE \* MERGEFORMAT 13 Myrobalan extracts and drug-containing serum on rat liver cell injury research Of: Li Gang, Zhang Shuyu, Wang Yuhua, off beach, Peng Yunshou [Abstract] Objective To observe myrobalan extracts and containing serum on CCl4 induced liver injury in rats, and discussed the mechanism of liver function. Methods Ⅳ collagenase perfusion isolated rat liver cells were cultured in vitro with CCl4 (20mmol / L) induced liver cell injury, using light microscopy, MTT method, and MDA detection, observation myrobalan extracts and hepatoprotective effect of drug-containing serum, and by detecting the corresponding activities of antioxidant enzymes on the protection preliminary study of liver function. Results myrobalan extracts and containing serum has significant hepatoprotective effect of myrobalan extract (0.8,1 mg / L) and 0.9 g / kg of the prepared containing serum can improve the CCl4 induced changes in cell morphology, cell viability increased significantly, can inhibit the CCl4 induced liver cell lipid peroxidation, and SOD and increased lipid peroxidase activity of GSH-Px. Conclusion myrobalan extracts and serum with this drug hepatoprotective effect, this effect and enhance the activity of antioxidant enzymes. [Keywords:] myrobalan; liver injury; antioxidant Terminalia chebula is one commonly used in traditional Chinese medicine, published in lt;”China Pharmacopoeiagt;gt; [1]. Myrobalan plant is Combretaceae Terminalia Terminalia Terminalia chebula Retz or down Tchebulm Retz var tomentella Kurt dry ripe fruit, production in India and Sri Lanka, also the production of Yunnan. myrobalan convergence with lung astringent intestinal diarrhea, pathogenic fire Liyan effect. Terminalia chebula main component of acid (chebulinic acid), blame Lile acid (chebulagicacid), 1 , 3, 6 - three galloyl glucose, [2]. recent reports have triterpenoids, multiple phenolic acids, aliphatic compounds and amino acids, minerals and other ingredients [3]. pharm