Neurotrophic factor receptor in Progress.doc

 PAGE \* MERGEFORMAT 32 Neurotrophic factor receptor in Progress [Keywords:] neurotrophic factor; receptor; signal transduction Family of neurotrophic factors in nerve cell growth and development, protection of the repair process plays an important role. And start neurotrophic factor receptor signal transduction, biological effects produced important material. According to the size of homology, gene expression location and the role of specific proteins and the different signaling mechanisms can be divided into three families of neurotrophic factors: nerve growth factor family, ciliary neurotrophic factor family and glial cell line derived neurotrophic factor. In this paper, the structure , function, signal transduction mechanisms, so its receptors in the latest research reviewed in the paper. 1, nerve growth factor receptor family Key members of the nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (neurotrophin 3, NT 3), neurotrophin 4 / 5 (neurotrophin 4 / 5, NT 4 / 5). These factors most representative of the receptor for the high affinity receptor (Trk) and low-affinity receptor (p75NTR), p75NTR receptor belonging to tumor necrosis factor receptor family. 1.1 Trk receptor 1.1.1 Trk Trk receptor family structure, including TrkA (p140Trk, mainly with NGF), TrkB (p145Trk, mainly with BDNF, NT 4 / 5) and TrkC (relative specific binding NT 3). They are in different stages of development, different tissues express different nerve cells, and nerve growth factor family of biological effects mainly mediated by the high affinity receptor, so obviously stage-specific expression and tissue specificity. Trk outer membrane structure, including a unique IgG C2 area and rich in cysteine, leucine repeat structure, previous studies confirm that growth factor binding site is located in the second immunoglobulin-like repeats, and its amino acid sequence order determines the specificity of the different Trk receptors and