NF κB Progress in drug research and cancer prevention and treatment.doc

 PAGE \* MERGEFORMAT 24 NF κB Progress in drug research and cancer prevention and treatment Keywords: NF  κB; cancer prevention; drug screening NF  κB (nuclear factor  kappa B, NF  κB) by regulating the expression of multiple genes involved in immune response, inflammation, apoptosis, tumorigenesis and metastasis and other biological processes [1,2]. In the resting state, NF  κB in the cytoplasm with its inhibitory factor IκBs combine to form complex, in a non-activated state; when cells are subject to various cells, the role of internal and external stimuli, IκBs was phosphorylated IκB kinase complex (IKK ), after phosphorylation, and ubiquitin protein binding, after degradation by the proteasome, allowing NF  κB released, and further translocation to the nucleus, in the activated state [3]. In recent years, with the development of molecular biology techniques in the study of NF  κB pathway can affect tumor cell apoptosis and how to determine the expression of apoptosis-related components to enhance or inhibit certain progress has been made, but these mechanisms are developed for the new The molecular target for cancer prevention and control of drugs has opened up a new way [4]. In this paper, related to NF  κB as a molecular target for drug research and its application in drug screening, etc. to make a brief overview. 1 NF  κB activity of activator and inhibitor In recent years, domestic and international pharmaceutical R amp; D institutions, pharmaceutical companies have launched against the NF  κB a wide range of drug research and found a series of acting on the NF  κB pathway compounds, can mainly be divided into two categories, one type NF  κB activity of activator; and those for the activity of NF  κB inhibitors. Activator NF  κB activity can enhance the body’s immune capacity to maintain a stable environment in the body. Also, study found that the activation of NF  κB may also contribute to the pr