Nitrous oxide in rats after poisoning four multifocal ERG changes in.doc

 PAGE \* MERGEFORMAT 11 Nitrous oxide in rats after poisoning four multifocal ERG changes in Author: Qiu Chang-Yu Hu Lina Ling Zhao Hongxin Luo Yan Li Jianzhong Li Zhisheng 【Abstract】 Objective: To study the effect of the space propellant nitrogen tetroxide post-exposure multifocal ERG changes. Methods: Normal male Winstar rats, with 15mg nitrogen tetroxide solution ip exposure, 1h and 7d examined rats 6 to 10, a fixed time at night sodium phenobarbital ip anesthesia and multifocal ERG Figure examination. That comes with the Microsoft Excel statistical software for data analysis. Results: The nitrogen tetroxide 15mg group of rats 1h after exposure of normal rats, the sum of MERG spread the ring b-wave latency difference was significant (P = 0.005 ~ 0.034, P lt;0.05); after exposure 7d rats and normal rats, the sum of MERG spread the ring b-wave latency difference is not statistically significant; two groups of rats and normal rats exposed to the sum of MERG affect the ring b-wave amplitude was no significant difference between the value of significance. 1h post-exposure group and exposure group after 7d spread between the MERG sum of all ring b-wave latency difference between some of its indicators are statistically significant (P = 0.006 ~ 0.017, P lt;0.05), no difference in the rest of indicators significant; and amplitude difference between the two groups was not significant. Conclusion: 1h and 7d four nitrous oxide in rats exposed to differences in incubation period of MERG part of their indicators are significant, MERG sum of all ring b-wave latency affected to varying degrees of differences, extended their influence weakened over time. Keywords: multifocal ERG in rats dinitrogen tetroxide Features of multifocal electroretinogram of N2O4 injected mice at different time Abstract AIM: To record multifocal electroretinogram from N2O4 injected mice at different time. In order to provide a found for further study. METHODS: Six to T