Novel interferon-IFN-λ s of the Research.doc

 PAGE \* MERGEFORMAT 16 Novel interferon-IFN-λ s of the Research [Abstract] Ⅲ type of interferon that IFN-λ s is a new type of interferon, the family, including IFN-λ 1, IFN-λ 2 and IFN-λ 3 (also respectively known as IL-29, IL-28A and IL-28B); IFN-λ s of the functional receptor complex is a CRF2-12 (IFN-λ -R1/IL-28Rα ) and CRF2-4 (IL10-R-β ) chains of heterodimers, IFN-λ s integrated into the receptors induced by receptor heterodimers, resulting in the Jak-Stat signal transduction pathway activation, thus playing with type Ⅰ similar biological effects of interferon, IFN-λ s biological effects include antiviral activity, anti-tumor proliferation, regulate Th1, Th2 and human cytokine response, regulate immune activity, treatment of diseases and so on. IFN-λ s anti-proliferative function of type Ⅰ interferon than the strong, suggesting that the bone marrow suppression in type Ⅰ interferon lower than that for the IFN-λ s clinical application of new ideas. [Keywords:] Interferon λ * Ⅰ interferon receptor, interferon According to interferon (IFNs) identify the amino acid sequence and specificity of different receptors can be divided into type Ⅰ , Ⅱ -type and the newly discovered type Ⅲ . Type Ⅰ interferon includes IFN-α , IFN-β , IFN-δ , IFN-κ , IFN-ω and IFN-τ . IFN-α and 13 subtypes; IFN-β only 1 subtypes, Ⅱ type only 1 types of interferon: IFN-γ ; Ⅲ type of interferon that IFN-λ s is a new type of interferon, including IFN-λ 1 , IFN-λ 2 and IFN-λ 3, also respectively known as interleukin 29 (IL-29), IL-28A and IL-28B [1]. λ interferon in human widespread in a variety of organizations, including the liver, pancreas, colon, lung and placenta, have recently found to have anti-HBV, HCV and anti-liver cancer and lung cancer and other biological functions. 1 IFN-λ Family And IL-22 receptor α -chain in a homologous CRF2-12 molecule was found as well as interferon-α ( ‘Zcyto21’) related to the success of an orphan ligand depicts the end, the IFN-λ f