Nucleoside (acid) class of antiviral medicine after 2 years into efficacy of antiviral treatment of hepatitis B.doc

 PAGE \* MERGEFORMAT 10 Nucleoside (acid) class of antiviral medicine after 2 years into efficacy of antiviral treatment of hepatitis B [Abstract] Objective To investigate the nucleoside (acid) class anti-viral drug withdrawal method of “step down” effect of withdrawal method. Method for initial 3 months to lamivudine and adefovir dipivoxil combined with, and then select One last until 2 years, 2 years after the treatment group A switch to the “double tiger Liver capsule Phyllanthus particles + + Astragalus Liquid” and then discontinued treatment for 6 months observation, the treatment group B is replaced by “bitterness Participation Capsule “and then discontinued treatment for 6 months observation, the control group to 2 years that withdrawal, the withdrawal rate observed three groups. A treatment group was significantly better than the other two groups, withdrawal rate was higher. Conclusion nucleoside (acid) class anti-virus markedly after 2 years to switch to the appropriate anti-viral medicine to six months after the discontinuation rate of withdrawal could increase, “De-escalation” withdrawal method may be effective. [Keywords:] Anti-virus; de-escalation; discontinuation rates Antiviral treatment of chronic hepatitis B has become a consensus, especially nucleoside (acid) is very significant class of antiviral drugs in the application of common, but difficult course of treatment given, the withdrawal is difficult for a consensus [1] Therefore, to improve the efficacy of our hospital to seek withdrawal of the policy were concluded long-term clinical observation and were found to “step down” treatment has shown signs of a method similar effect, are as follows. 1 Materials and Methods 1.1 General information on this case are selected from our hospital since February 2005 -2006 3 years of secondary inspection period and other clinical and diagnosed as “viral hepatitis B, chronic” cases, and to further screen out “first 3 months to Lamy Telbivudi